OASIS Brains

Open Access Series of Imaging Studies

The Open Access Series of Imaging Studies (OASIS) is a project aimed at making neuroimaging data sets of the brain freely available to the scientific community. By compiling and freely distributing neuroimaging data sets, we hope to facilitate future discoveries in basic and clinical neuroscience.

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About the OASIS Brains project

OASIS-3 is the latest release in the Open Access Series of Imaging Studies (OASIS) that aimed at making neuroimaging datasets freely available to the scientific community. By compiling and freely distributing this multi-modal dataset, we hope to facilitate future discoveries in basic and clinical neuroscience. Previously released data for OASIS-Cross-sectional (Marcus et al, 2007) and OASIS-Longitudinal (Marcus et al, 2010) have been utilized for hypothesis driven data analyses, development of neuroanatomical atlases, and development of segmentation algorithms. OASIS-3 is a longitudinal neuroimaging, clinical, cognitive, and biomarker dataset for normal aging and Alzheimer’s Disease.

The OASIS datasets hosted by central.xnat.org provide the community with open access to a significant database of neuroimaging and processed imaging data across a broad demographic, cognitive, and genetic spectrum an easily accessible platform for use in neuroimaging, clinical, and cognitive research on normal aging and cognitive decline. All data is available via www.oasis-brains.org.

OASIS Brains Datasets

OASIS-3: Longitudinal Neuroimaging, Clinical, and Cognitive Dataset for Normal Aging and Alzheimer’s Disease

Subjects:

1098

MR Sessions:

2118

PET Sessions:

TBD

Summary: OASIS-3 is a retrospective compilation of data for >1000 participants that were collected across several ongoing projects through the WUSTL Knight ADRC over the course of 30 years. Participants include 609 cognitively normal adults and 489 individuals at various stages of cognitive decline ranging in age from 42-95yrs. All participants were assigned a new random identifier and all dates were removed and normalized to reflect days from entry into study. The dataset contains over 2000 MR sessions which include T1w, T2w, FLAIR, ASL, SWI, time of flight, resting-state BOLD, and DTI sequences. Many of the MR sessions are accompanied by volumetric segmentation files produced through Freesurfer processing. PET imaging from 3 different tracers, PIB, AV45, and FDG, totaling over 1500 raw imaging scans and the accompanying post-processed files from the Pet Unified Pipeline (PUP) are also available in OASIS-3.

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Scripted Download Instructions

Browse Data OASIS-3 Data Dictionary

OASIS-2: Longitudinal MRI Data in Nondemented and Demented Older Adults

Subjects:

150

MR Sessions:

373

Summary: This set consists of a longitudinal collection of 150 subjects aged 60 to 96. Each subject was scanned on two or more visits, separated by at least one year for a total of 373 imaging sessions. For each subject, 3 or 4 individual T1-weighted MRI scans obtained in single scan sessions are included. The subjects are all right-handed and include both men and women. 72 of the subjects were characterized as nondemented throughout the study. 64 of the included subjects were characterized as demented at the time of their initial visits and remained so for subsequent scans, including 51 individuals with mild to moderate Alzheimer’s disease. Another 14 subjects were characterized as nondemented at the time of their initial visit and were subsequently characterized as demented at a later visit.

Publications

Open Access Series of Imaging Studies (OASIS): Longitudinal MRI Data in Nondemented and Demented Older Adults
Marcus, DS, Fotenos, AF, Csernansky, JG, Morris, JC, Buckner, RL, 2010. Journal of Cognitive Neuroscience, 22, 2677-2684. doi: 10.1162/jocn.2009.21407

Get Data

FTP Download Instructions

Browse Data Download CSV

OASIS-1: Cross-sectional MRI Data in Young, Middle Aged, Nondemented and Demented Older Adults

Subjects:

416

MR Sessions:

434

Summary: This set consists of a cross-sectional collection of 416 subjects aged 18 to 96. For each subject, 3 or 4 individual T1-weighted MRI scans obtained in single scan sessions are included. The subjects are all right-handed and include both men and women. 100 of the included subjects over the age of 60 have been clinically diagnosed with very mild to moderate Alzheimer’s disease (AD). Additionally, a reliability data set is included containing 20 nondemented subjects imaged on a subsequent visit within 90 days of their initial session.

Publications

Open Access Series of Imaging Studies (OASIS): Cross-Sectional MRI Data in Young, Middle Aged, Nondemented, and Demented Older Adults
Marcus, DS, Wang, TH, Parker, J, Csernansky, JG, Morris, JC, Buckner, RL. Journal of Cognitive Neuroscience, 19, 1498-1507. doi: 10.1162/jocn.2007.19.9.1498

Get Data

FTP Download Instructions

Browse Data Download CSV Download Reliability Data Fact Sheet


All OASIS data use requires acceptance of the Data Use Agreement

Publications for Citations

Authors of publications or presentations using OASIS data should cite relevant publications describing the methods used by the OASIS to acquire and process the data. The specific publications that are appropriate to cite in any given study will depend on what OASIS data were used and for what purposes.

When publishing findings that benefit from OASIS data, please include the following grant numbers in the acknowledgements section and in the associated Pubmed Central submission: P50 AG05681, P01 AG03991, R01 AG021910, P50 MH071616, U24 RR021382, R01 MH56584.

Related Publications

Normative estimates of cross-sectional and longitudinal brain volume decline in aging and AD.
Fotenos, AF, Snyder, AZ, Girton, LE, Morris, JC, and Buckner, RL, 2005. Neurology, 64: 1032-1039. doi: 10.1212/01.WNL.0000154530.72969.11
A unified approach for morphometric and functional data analysis in young, old, and demented adults using automated atlas-based head size normalization: reliability and validation against manual measurement of total intracranial volume.
Buckner, RL, Head, D, Parker, J, Fotenos, AF, Marcus, D, Morris, JC, Snyder, AZ, 2004. Neuroimage 23, 724-38. doi: 10.1016/j.neuroimage.2004.06.018
Segmentation of brain MR images through a hidden Markov random field model and the expectation maximization algorithm.
Zhang, Y, Brady, M, Smith, S, 2001. IEEE Trans. on Medical Imaging, 20(1):45-57. doi: 10.1109/42.906424
A prospective study of cognitive function and onset of dementia in cognitively healthy elders.
Rubin, EH, Storandt, M, Miller, JP, Kinscherf, DA, Grant, EA, Morris, JC, Berg, L, 1998. Arch Neurol. 55, 395-401. PMID: 9520014
The Clinical Dementia Rating (CDR): current version and scoring rules.
Morris, JC, 1993. Neurology 43, 2412b-2414b. PMID: 8232972

Data Use Agreement

The OASIS data are distributed the greater scientific community under the Creative Commons Attribution 4.0 license with the following additional terms:

  1. You will not attempt to establish the identity of to make contact with any of the included human participants.
  2. You will acknowledge the use of OASIS data and data derived from OASIS data when publicly presenting any results or algorithms that benefitted from their use. Papers, book chapters, books, posters, oral presentations, and all other printed and digital presentations of results derived from OASIS data should contain the following:
    1. Acknowledgments: "Data were provided [in part] by OASIS [insert appropriate OASIS source info]”
      1. OASIS-3: Principal Investigators: T. Benzinger, D. Marcus, J. Morris; NIH P50AG00561, P30NS09857781, P01AG026276, P01AG003991, R01AG043434, UL1TR000448, R01EB009352. AV-45 doses were provided by Avid Radiopharmaceuticals, a wholly owned subsidiary of Eli Lilly.
      2. OASIS: Cross-Sectional: Principal Investigators: D. Marcus, R, Buckner, J, Csernansky J. Morris; P50 AG05681, P01 AG03991, P01 AG026276, R01 AG021910, P20 MH071616, U24 RR021382
      3. OASIS: Longitudinal: Principal Investigators: D. Marcus, R, Buckner, J. Csernansky, J. Morris; P50 AG05681, P01 AG03991, P01 AG026276, R01 AG021910, P20 MH071616, U24 RR021382
    2. Citation: The specific publications that are appropriate to cite in any given study will depend on what OASIS data were used and for what purposes. An annotated and current list of OASIS publications is available at http://www.oasis-brains.org.
    3. All proposed publications or presentations using Florbetapir F18 (AV45) PET data must be submitted to Avid Radiopharmaceuticals for review and comment thirty days prior to such presentation or publication for review of intellectual property interests. See Imaging data dictionary for contact information and details.
  3. You agree to provide the Knight ADRC upon request with information on your use of OASIS data
  4. Failure to abide by these data use terms may result in termination of your right to access and use OASIS data.

Who Can Obtain Access?

By submitting the data request I am agreeing to abide by the terms of this data use Agreement.

Data Dictionary & Documentation

These resources may be valuable to researchers using this data.

Imaging Data Dictionary And Methods

Description of imaging methods and variables for OASIS-3

UDS Data Dictionary

Explaining the NIH Uniform Data System (UDS) data type

How To Use XNAT Central

Information on how to navigate, search, and download OASIS data on XNAT central

BIDS

Information on the BIDS data structure

Freesurfer

Information on Freesurfer Software used for OASIS-3 volumetric segmentation


Using XNAT Central

Searching, Reporting, and Data Mining

Searching XNAT Central
https://wiki.xnat.org/documentation/how-to-use-xnat/using-the-standard-search
Using the Advanced Search
https://wiki.xnat.org/documentation/how-to-use-xnat/using-the-standard-search/using-the-advanced-search
Saving a Data Table as a Stored Search
https://wiki.xnat.org/documentation/how-to-use-xnat/using-the-standard-search/saving-a-data-table-as-a-stored-search
How to Edit and Filter Datatypes and Join Tables
https://wiki.xnat.org/documentation/how-to-use-xnat/using-the-standard-search/how-to-edit-filter-and-join-data-tables

Downloading Data

Downloading Image Sessions from the UI
https://wiki.xnat.org/documentation/how-to-use-xnat/how-to-download-image-data-from-xnat-projects
Downloading Files via the XNAT REST API
https://wiki.xnat.org/display/XAPI/How+To+Download+Files+via+the+XNAT+REST+API
* Recommended for large imaging dataset downloads
Troubleshooting XNAT Java Applet Issues
https://wiki.xnat.org/documentation/how-to-use-xnat/image-session-upload-methods-in-xnat/troubleshooting-xnat-java-applet-issues
BIDS Downloader
(coming soon)

Frequently Asked Questions

Should I combine OASIS-1, OASIS-2, and OASIS-3 datasets?
No.
Can I request more data?
No. All available data is included in central.xnat.org
Dataset DOI
Each subject and data session receives a unique XNAT accession/ID number. For downloaded imaging sessions this can be found in the dataset_description.json file.
Ex. of Subject ID/Accession#: CENTRAL_S05094
"Dataset DOI": https://central.xnat.org/data/archive/projects/OASIS3/subjects/CENTRAL_S06136/experiments/CENTRAL_E11128

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